Sarcomas and Histiocytosis
Research Program
Leaders
Where we are
SJD Barcelona Children's Hospital
Related websites
SJD Barcelona Children’s Hospital Our group aims to generate a knowledge base on developmental sarcomas and Langerhans cell histiocytosis (LCH) with a view to improving diagnosis, prognosis and treatment.
Since 2014 we have been a consolidated AGAUR research group (Government of Catalonia, references 2014 SGR 1398 and 2017 SGR 1672).
Research lines
Our specific activities are:
- The study of the aetiology of sarcomas and LCH and the phenotypic and genotypic characterisation of the different clinical subtypes.
- The investigation of the existence of cancer stem cells or progenitor cells.
- Improving treatments for patients with sarcomas by studying preclinical pharmacology.
- The development of IGF-1R-targeted therapies for sarcoma.
- The study of molecular pathways and therapies aimed at histiocytosis.
- Paediatric Cancer Epigenetics
Scientific objectives
- To develop innovative pharmacological treatments for extracranial paediatric solid tumours such as Ewing's sarcoma, rhabdomyosarcoma, osteosarcoma and LCH.
- To describe the cell of origin in Ewing's sarcoma and to develop experimental models to reproduce the tumourigenesis process.
Area/Field of expertise
Development of cell models and patient-derived xenografts (PDX) of paediatric solid tumours (rhabdomyosarcoma, Ewing's sarcoma, osteosarcoma, Wilms tumour, germ cell tumours) from biobank samples.
Efficacy tests of anticancer agents used to treat paediatric solid tumours.
Epigenomics and chromatin conformation studies using chip-Seq, CHIP-CHIP, HI-Seq.
Group members
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Jefe de Grupo Senior
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Maria Inmaculada Hernandez Muñoz
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Last Publications
- Ana Carolina Izurieta Pacheco, Sangrós-Gimenez A, Martínez-Garcia E, Pérez-Jaume S, Mora J and Gorostegui-Obanos M Vitamin D Status in Children With High-risk Neuroblastoma. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY . 45(8): .
- Muñoz JP, Cristina Larrosa Espinosa, Chamorro S, Pérez-Jaume S, Simao M, Sanchez-Sierra N, Varo A, Gorostegui-Obanos M, Castañeda-Heredia A, Garraus-Oneca M, Lopez-Miralles S and Mora J Early Salvage Chemo-Immunotherapy with Irinotecan, Temozolomide and Naxitamab Plus GM-CSF (HITS) for Patients with Primary Refractory High-Risk Neuroblastoma Provide the Best Chance for Long-Term Outcomes. Cancers . 15(19): .
- Gomez-Gonzalez S, Llano J, Garcia-López M, Garrido- García A, Suñol M, Lemos I, Pérez-Jaume S, Salvador-Marcos N, Gene-Olaciregui N, Galán RA, Santa-María López V, Pérez-Somarriba M, Castañeda-Heredia A, Hinojosa J, Winter U, Moreira FB, Lubieniecki F, Vazquez V, Mora J, Cruz-Martínez O, Morales-La Madrid A, Perera A and Lavarino C EpiGe: A machine-learning strategy for rapid classification of medulloblastoma using PCR-based methyl-genotyping. iScience . 26(9): 107598-107598.
Projects
- Project name:
- Ayuda Ramon y Cajal. Beneficiari: Sandra Castillo
- Leader
- Sandra Castillo Diez
- Funding entities:
- Ministerio De Ciencia E Innovacion
- Code
- RYC2022-035574-I
- Starting - finishing date:
- 2024 - 2029
- Project name:
- Subvenció per a la incorporació de personal de suport als grups de recerca, corresponent als anys 2023-2025
- Leader
- Jaume Mora Graupera
- Funding entities:
- Generalitat de Catalunya
- Code
- SLT028/23/000308
- Starting - finishing date:
- 2023 - 2026
- Project name:
- SGR 2022-2024_Grup de recerca en tumors del desenvolupament
- Leader
- Jaume Mora Graupera
- Funding entities:
- Agaur - Agència de Gestió d'Ajuts Universitaris i de Recerca
- Code
- 2021 SGR 01612
- Starting - finishing date:
- 2022 - 2025
Theses
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Target Therapy in Rhabdomyosarcoma: Discovering new targets and apportunities
- Author
- Prada Varela, Estela
- Institution
- UNIVERSIDAD DE BARCELONA
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Combined therapies for neuroblastoma based on the activation of the calcium sensing receptor
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- Gonçalves Alves, Eliana Carolina
- Institution
- UNIVERSIDAD DE BARCELONA
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Polycomb and KDM6A Roles in the Epigenetic Dynamics of Ewing Sarcoma Tumorigenesis”
- Author
- Figuerola Bou, Elisabet
- Institution
- UNIVERSIDAD DE BARCELONA
News
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New discoveries about the EWS-FLI oncogene involved in the development of Ewing's tumor
Researchers from IRSJD · SJD Barcelona Children’s Hospital and IRB Barcelona have successfully developed Drosophila models expressing the EWS-FLI oncogene at varying levels, overcoming previous toxicity challenges and enabling detailed study of Ewing sarcoma's oncogenic pathways.
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The Catalan Tumour Bank Network launches a new corporate identity and website
The Xarxa de Bancs de Tumor de Catalunya (XBTC) has renewed its corporate identity and website to project a more dynamic and local network in the biomedicine and health ecosystem.
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New research facilities for studying children's cancer
New facilities have been opened for the children's oncology laboratory of the Institut de Recerca Sant Joan de Déu - SJD Barcelona Children's Hospital to celebrate 20 years of research. These laboratories are unique in their exclusive dedication to pediatric tumors and have over 50 researchers who focus on the study of more than ten developmental tumors.
More activities
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Defensa tesi doctoral: María Sánchez Jiménez
Auditori Plaza · Hospital Sant Joan de Déu and online
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First International Symposium on Transdisciplinary Approaches for Neuroblastoma Therapy
Auditorium SJD Pediatric Cancer Center Barcelona
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Defensa tesi doctoral: Sara Pérez Jaume
Auditorio J Plaza del Hospital Sant Joan de Déu y online