Sandra Castillo Diez
Investigador
Research group
Sandra Castillo completed her PhD in cancer genetics at the Spanish National Cancer Research Center (CNIO, Madrid) and the Bellvitge Biomedical Research Institute (IDIBELL, Barcelona) focusing on the impact of novel oncogenes in cancer development.
In 2012 she joined Prof. Bart Vanhaesebroeck's lab at the Cancer Institute, University College London, where she researched the role of PI3K signaling in cancer and rare congenital disorders. During this time, she identified new genetic mutations associated with vascular anomalies. In 2017, she joined Dr. Mariona Graupera's lab at IDIBELL and the Josep Carreras Research Institute. There, she explored novel genetic and molecular drivers of vascular malformations and developed preclinical models and studies.
Currently, she leads the Pathobiology of Vascular Tumours and Malformations group at the SJD Pediatric Cancer Center. Her primary focus is to unravel the genetic and molecular causes of pediatric vascular tumors and malformations, with the aim of developing new preclinical models and therapeutic strategies. The group is also interested in endothelial dynamics in tumour angiogenesis.
Professional network profiles
Last Publications
- Conduit SE, Pearce W, Bhamra A, Bilanges B, Bozal-Basterra L, Foukas LC, Cobbaut M, CastilloSD, Danesh MA, Adil M, Carracedo A, Graupera M, McDonald NQ, Parker PJ, Cutillas PR, Surinova S and Vanhaesebroeck B A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease. NATURE COMMUNICATIONS . 15(1): 7181-7181.
- Serra F, Nieto-Aliseda A, Fanlo-Escudero L, Rovirosa L, Cabrera-Pasadas M, Lazarenkov A, Urmeneta B, Alcalde-Merino A, Nola EM, Okorokov AL, Fraser P, Graupera M, CastilloSD, Sardina JL, Valencia A and Javierre BM p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response. NATURE COMMUNICATIONS . 15(1): 2821-2821.
- Cerdà P, CastilloSD, Aguilera C, Iriarte A, Rocamora JL, Larrinaga AM, Viñals F, Graupera M and Riera-Mestre A New genetic drivers in hemorrhagic hereditary telangiectasia. EUROPEAN JOURNAL OF INTERNAL MEDICINE . 119: 99-108.
Projects
- Project name:
- Ayuda Ramon y Cajal. Beneficiari: Sandra Castillo
- Leader
- Sandra Castillo Diez
- Funding entities:
- Ministerio De Ciencia E Innovacion
- Code
- RYC2022-035574-I
- Starting - finishing date:
- 2024 - 2029
- Project name:
- Laboratori contra el càncer
- Leader
- Jaume Mora Graupera
- Funding entities:
- Clientes Diversos
- Code
- CGC00004
- Starting - finishing date:
- 2008 - 3000