#SeminarIRSJD · Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in neuroblastoma

• Dra. Marta García, investigadora del grupo Genómica Traslacional · IRSJD

Seminario exclusivo para personal de la institución.

El seminario se realizará en español.

Resumen

Patients with high-risk neuroblastoma are treated with intensive multimodal therapy, however, approximately 60% of patients that initially respond to chemotherapy will eventually suffer disease relapse and/or develop resistance to therapy. Acquisition of resistance to chemotherapeutic drugs is thus a major problem, leading to treatment failure. We have investigated the molecular mechanisms of therapy-induced resistance in high-risk neuroblastoma tumors, to identify activated signaling pathways that promote cell survival, and may represent potential therapeutic targets. By using high-throughput screening strategies, we have identified active compounds against our drug-resistant neuroblastoma cell lines, providing insights into potential vulnerabilities of interest for therapeutic opportunities