People / Staff

Silvia Mateo Lozano

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Publications

  • Mateo-Lozano S.

    Pyrazolo[1,5-a]-1,3,5-triazine as a Purine Bioisostere: Access to Potent Cyclin-Dependent Kinase Inhibitor (R)-Roscovitine Analogue

    JOURNAL OF MEDICINAL CHEMISTRY . 52(3): 655-663. Number of citations: 78

    [doi:10.1021/jm801340z]

  • Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schächtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V and Meijer L.

    Meriolins, a new class of cell death-inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

    CANCER RESEARCH . 67(17): 8325-8334. Number of citations: 111

    [doi:10.1158/0008-5472.CAN-07-1826]

  • Mateo-Lozano S, Gokhale PC, Soldatenkov VA, Dritschilo A, Tirado OM and Notario V.

    Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma

    CLINICAL CANCER RESEARCH . 12(22): 6781-6790. Number of citations: 49

    [doi:10.1158/1078-0432.CCR-06-0609]

  • Tirado OM, Mateo-Lozano S, Villar J, Dettin LE, Llort A, Gallego S, Ban J, Kovar H and Notario V.

    Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells.

    CANCER RESEARCH . 66(20): 9937-9947. Number of citations: 110

    [doi:10.1158/0008-5472.CAN-06-0927]

  • Tirado OM, Mateo-Lozano S and Notario V.

    Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo

    CANCER RESEARCH . 65(20): 9320-9327. Number of citations: 56

    [doi:10.1158/0008-5472.CAN-05-1276]

  • Tirado OM, Mateo-Lozano S and Notario V.

    Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax: Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity

    Oncogene . 24(20): 3348-3357. Number of citations: 67

    [doi:10.1038/sj.onc.1208471]

  • Mateo-Lozano S, Tirado OM and Notario V.

    Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation

    Oncogene . 22(58): 9282-9287. Number of citations: 96

    [doi:10.1038/sj.onc.1207081]

  • Tirado OM, Mateo-Lozano S, Sanders S, Dettin LE and Notario V.

    The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation

    CANCER RESEARCH . 63(19): 6290-6298. Number of citations: 24