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E-Rare-3 Call for Proposals 2017 (JTC 2018) : "Transnational research projects on hypothesis-driven use of multi-omic integrated approaches for discovery of disease causes and/or functional validation in the context of rare diseases"


Convocatòria tancada
Entitat convocant:
European Commission
Àmbit:
Internacional
Inici:
Termini intern:
Termini real:
Descripció:

Objectiu de la convocatòria


The aim of the E-Rare Joint Transnational Calls (JTCs) is to enable scientists in different countries to build an effective collaboration on a common interdisciplinary research project based on complementarities and sharing of expertise, with a clear translational research approach.

Projects shall involve a group of rare diseases or a single rare disease following the European definition i.e. a disease affecting not more than five in 10000 persons in the European Community, EC associated states and Canada.

The research projects have to focus on hypothesis-driven use of multi-omic integrated approaches for discovery of disease causes and/or on functional validation in the context of rare diseases.

 

Característiques principals


Transnational research proposals must cover at least one of the following areas, which are equal in relevance for this call:

a. Combined multi-omics approaches (e.g. epigenomics, transcriptomics, metabolomics, proteomics, etc.) that complement genomics-based gene discovery strategies and that are driven by a lead hypothesis. These multi-omics approaches should extend beyond descriptive “-omics” data gathering, such as simple whole exome/genome sequencing for disease gene discovery. For transcriptomic and proteomic data, a strong rationale for physiological relevance of the collected sample/tissue/dataset must be available;
b. Functional validation of clinical or biological inferences obtained from “-omics” results, e.g. by

 

  • developing new computational, statistical and experimental methods for analysis and interpretation of existing multi-omic datasets or for the identification of relevant biomarkers;
  • integrating the already obtained “-omics” results to generate and test new biological models;
    c. Application of “-omics” approaches to rare diseases for which the gene(s) is/are known to enable insight into disease pathophysiology. Emphasis will be given to approaches that transcend a single “-omics” approach to illuminate pathomechanism. Projects that generate “-omics” data with limited integration and interpretation will be considered lower priority;
    d. Development and application of concepts and methods for pathogenic read-outs of disease groups which can be used as “blue print” to discover new disease genes and inform pathomechanism. Projects on “simple” or “pure” gene hunts will be discouraged if they can be rationally performed at a single institution or by existing international resource centers, with the exception of studies that inform fundamentally new genetic paradigms.

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    Requisits


    Only transnational projects will be funded. Each consortium submitting a proposal must involve a minimum of three eligible and a maximum of six eligible partners from at least three different countries participating to the call. No more than two eligible partners from the same country participating in the call will be accepted in one consortium.

    Applicants are encouraged to include partners from the participating underrepresented countries (Czech Republic, Hungary, Latvia, Poland, Romania and Turkey). If they include such partners, the maximum number of eligible partners can be increased to eight.

    Additional partners that secure their own funding may join consortia. However, their number is limited to two. The consortium coordinator must always be eligible to receive funding from the funding organisations participating in the call.

    Whilst applications will be submitted jointly by groups from several countries, individual groups will be funded by the individual E-Rare-3 funding organisation respective of the country from which applicants have applied. The applications are therefore subjected to eligibility criteria of individual funding organisations.

    For Spanish applicants: please check the eligibility requirements of the institution and the principal investigator/team members, in pages 37-38 of the Guidelines.

    Applicants are strongly advised to contact their national representative and confirm eligibility with their respective funding organisations in advance of submitting an application.

     

    Dotació


    The funding depends on national/regional rules. For Spanish entities, up to € 200,000 for coordinators and € 150,000 for partners.

     

    Durada


    3 years

     

    Documentació


    There will be a two-stage submission procedure for joint applications: pre-proposals and full proposals.

     

  • Deadline for submitting the pre-proposals: February 1, 2017
  • Communication of selection of pre-proposals: End of April, 2017
  • Indicative deadline for submitting the full proposals: June 2, 2017

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    Convocatòria (URL)


    http://www.erare.eu/joint-call/10th-joint-call-european-research-projects-rare-diseases-jtc-2018