Horizon Europe's Cluster 1 (Health) under Pillar II supports collaborative research and innovation to improve health outcomes, strengthen healthcare systems, and address major public health challenges across Europe. The programme funds collaborative projects, coordination and support activities, and complementary actions across a wide range of health-related topics. The 2026 topics of interest follow a single-stage application process, with a submission deadline of 16 April 2026, and support the following types of actions: Research and Innovation Actions (RIA), Innovation Actions (IA), Coordination and Support Actions (CSA), and Public Procurement of Innovative Solutions (PPI), aiming to promote transformative solutions, foster innovation, and enhance the impact of health research at European level.

The 2026 topics are:

• Destination 1: Staying healthy in a rapidly changing society

  • 2026 HORIZON-HLTH-2026-01-STAYHLTH-02: Behavioural interventions as primary prevention for Non-Communicable Diseases (NCDs) among young people

  • 2026 HORIZON-HLTH-2026-01-STAYHLTH-03: Building public trust and outreach in the life sciences

• Destination 2: Living and working in a health-promoting environment

  • 2026 HORIZON-HLTH-2026-01-ENVHLTH-01: Towards a better understanding and anticipation of the impacts of climate change on health

  • 2026 HORIZON-HLTH-2026-01-ENVHLTH-04: Towards climate resilient, prepared and carbon neutral populations and healthcare systems

  • 2026 HORIZON-HLTH-2026-01-ENVHLTH-05: Support for a multilateral initiative on climate change and health research

• Destination 3: Tackling diseases and reducing disease burden

  • 2026 HORIZON-HLTH-2026-01-DISEASE-02: Innovative interventions to prevent the harmful effects of using digital technologies on the mental health of children and young adults

  • 2026 HORIZON-HLTH-2026-01-DISEASE-03: Advancing research on the prevention, diagnosis, and management of post-infection long-term conditions

  • 2026 HORIZON-HLTH-2026-01-DISEASE-04: Development of novel vaccines for viral pathogens with epidemic potential

  • 2026 HORIZON-HLTH-2026-01-DISEASE-09: Multisectoral approach to tackle chronic non-communicable diseases: implementation research maximising collaboration and coordination with sectors and in settings beyond the healthcare system (GACD)

  • 2026 HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways

  • 2026 HORIZON-HLTH-2026-02-DISEASE-12: European Partnership on Rare Diseases (ERDERA) (Phase 2)

  • 2026 HORIZON-HLTH-2026-03-DISEASE-13: European Partnership for Pandemic Preparedness (Phase 2)

  • 2026 HORIZON-HLTH-2026-01-DISEASE-15: Scaling up innovation in cardiovascular health

• Destination 4: Ensuring equal access to innovative, sustainable, and high-quality healthcar

  • 2026 HORIZON-HLTH-2026-01-CARE-01: Public procurement of innovative solutions for improving citizens' access to healthcare through integrated or personalised approaches

  • 2026 HORIZON-HLTH-2026-01-CARE-03: Identifying and addressing low-value care in health and care systems

• Destination 5: Developing and using new tools, technologies and digital solutions for a healthy society

  • 2026 HORIZON-HLTH-2026-01-TOOL-03: Integrating New Approach Methodologies (NAMs) to advance biomedical research and regulatory testing

  • 2026 HORIZON-HLTH-2026-01-TOOL-05: Pilot actions for follow-on funding: Leveraging EU-funded collaborative research in regenerative medicine

  • 2026 HORIZON-HLTH-2026-01-TOOL-06: Support to European Research Area (ERA) action on accelerating New Approach Methodologies (NAMs) to advance biomedical research and testing of medicinal products and medical devices

  • 2026 HORIZON-HLTH-2026-01-TOOL-07: Establishing a European network of Centres of Excellence (CoEs) for Advanced Therapies Medicinal Products (ATMPs)

• Destination 6: Maintaining an innovative, sustainable, and competitive EU health industry

  • 2026 HORIZON-HLTH-2026-01-IND-03: Regulatory science to support translational development of patient-centred health technologies

Projects vary in duration and submission process; objectives include fostering innovation, improving healthcare, and addressing societal health challenges

• Open to any legal entity established in an EU Member State or an associated country, including research organizations, universities, hospitals, and industry partners.

• Research and Innovation Actions (RIA) and Innovation Actions (IA): transnational consortia required, composed of at least one legal entity established in an EU Member State and at least two additional entities from EU Member States or associated countries.

• Coordination and Support Actions (CSA): participation of one or more entities established in EU Member States or associated countries.

• Public Procurement of Innovative Solutions (PPI): transnational consortia required, composed of at least one legal entity established in an EU Member State and at least two entities from EU Member States or associated countries; at least two partners must be public buyers subject to public procurement rules, including one from an EU Member State and one from an EU Member State or an associated country.

• Specific eligibility criteria may vary by topic; please consult the official work programme for details.

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