Objectiu de la convocatòria

ERACoSysMed is the first Systems Medicine oriented ERA-NET under Horizon 2020. The 14 participating funding bodies agreed on a joint agenda to specifically support demonstrator projects that identify areas where a systems approach addresses a clinical question and provides solution strategies to clinical problems.

The aim of the call is to fund research projects that validate existing predictive computational models using biomedical data to expand the knowledge about human diseases and their treatment.

Característiques principals

As prerequisite for funding, each project must meet the following conditions:

• A multidisciplinary collaboration of clinicians, experimentalists, computational scientists, bioinformaticians, data management and curation experts, industrial partners and if possible, patient communities is expected. Each consortium must include at least one clinical group and a computational modelling group.

• The project must apply a systems medicine approach.

• Relevant patient data sets and patient samples, and well annotated archived samples should be available. New data may only be generated when it is necessary for the modelling cycle, therefore generation of new data cannot be a major part of the project. Patient recruitment should be completed at the time of application.

• Computational models based on high-quality datasets (sufficient deep phenotyping, curated data sets) should already exist.

• Clinical centers providing patients and their data should give evidence of the ethical and legal clearance for data sharing, patient consent for using the data for the purpose of the proposed project if applicable, as well as their data quality and suitability for computational analysis.

• A data management plan and data handling protocols according to international state-of-the-art standards (FAIR1 and GDPR2 compliant and secure) must be provided as an integral part of the application. A data management plan should address criteria such as data accessibility, format and storage, stewardship/curation, time plan and schedule for the submission date, quality of meta data, and data security. For this, it may help to follow the guiding questions found in the data management plan template in Horizon 20203 . Data storage, data/model exchange and data/model sharing agreements should be available at the time of application.

• The use of existing infrastructures (e.g. ELIXIR) should be taken into consideration.

• The application must contain a plan for involvement of different stakeholders. This plan describes how, why and when stakeholder involvement will be handled. Furthermore, it must describe how the project will benefit from the inclusion of the stakeholder(s). The benefit can e.g. be to develop a product the end-users need or welcome, to decrease financial burden on health care providers, or to facilitate public debate of the research. Stakeholders can be patients, health care providers, public bodies, medical professionals, companies, etc.

• Applications must fulfil the national ethical and legal requirements. For instance, among other things, special attention must be paid to ethical issues (e.g. research on humans or animals; privacy of data and biomaterials; informed consent; etc.). Please be aware that regulations and ethical issues vary among different countries and should be considered from the outset.

Requisits

Eligibility of projects:

Each consortium submitting a proposal must involve a minimum of three and a maximum of five eligible partners from at least three different countries participating in the call. For reasons of transnational balance, no more than two eligible partners from the same country are allowed to join each consortium.

Germany, Austria, Belgium, France, Italy, Luxembourg, The Netherlands, Norway, Slovakia, Spain.

Dotació

Spanish Partners

Durada

Up to three years

AVÍS IMPORTANT

The call will be implemented through a two-step evaluation procedure including submission and evaluation of pre-proposals (deadline 15th March) and full proposals (deadline 28th June).
Applicants must refer and comply with the specific regulations of the national funding organizations (see Annex II).
Important: After the international evaluation has taken place, all Spanish applicants invited to the full-proposal stage, must submit the project proposal along other documents, via ISCIIIs online submission tool.
If you intend to submit a proposal for this call, please contact lnorton@fsjd.org in order to check your eligibility.

Convocatòria (URL)

https://www.eracosysmed.eu/call3