Projectes

Codi

202414-30

Investigador/a principal

Maria Dolores Gómez Roig

Rol

Coordinador

Any d'inici

2025

Any de finalització

2028

Import total

100427,5€

Objectius

There is more and more evidence that indicates that the environment that surrounds us, from the moment we are conceived, but also during our childhood and adolescence [that is, how we eat and live, what our living habits are, or what the air is like that we breathe] influences our health, and more specifically our sexual and reproductive health.
Our objective is to investigate whether there is a relationship between our diet, our lifestyle habits (alcohol and tobacco consumption), the air we breathe or the pollutants to which we are exposed, during conception, childhood and early adulthood, with sexual and reproductive health. To this end, 4,000 pregnant women and their newborn children, from
different regions of Spain, have voluntarily provided information about their diet, habits and lifestyle, etc., during the first 14- 18 years of their children's lives. The participants have also donated biological samples (blood, urine, milk, etc.) where different clinical variables have been measured (blood count, pollutants, etc.). The quality of the water they drank and the
quality of the air they breathed are also known.
Now that the children are teenagers (or almost adults), they are between 16-22 years old, we propose to contact the
participants again to find out what their sexual and reproductive health is. We will perform a physical examination, and we
will ask how and when the onset of puberty occurred, we will evaluate ovarian function in girls, we will analyze the seminal
quality of boys, and we will study if they have gynecological pathologies such as endometriosis. We want to analyze, using
all the information available, both the information collected during the last 18 years, as well as the new information
generated with this project that we request, if it is possible to prevent the reproductive health problems that are detected.
The data generated will also improve clinical practice but will transcend this area, since it will be published on social
networks and different general media.
Strengthening scientific knowledge is the only way to make correct decisions, since it allows us to fill in the information
gaps that still exist and update scientific data for the development of appropriate environmental policies.

Codi

202417/30

Investigador/a principal

Lourdes Ibañez Toda

Rol

Coordinador

Any d'inici

2025

Any de finalització

2028

Import total

124200€

Objectius

Background: The pathophysiology of polycystic ovary syndrome (PCOS) is unclear, but reflects alterations in the homeostatic feedback mechanisms between the gonads, adipose tissue, and hypothalamic brain circuits. The development of genetic animal models of human PCOS provides valuable insight into the pathogenesis of the disorder. Objectives: Elucidate the pathogenesis of PCOS in a fly model (Drosophila melanogaster) with a PCOS-like phenotype and identify novel biomarkers for its early diagnosis in humans:
Aim 1. Characterization of the cellular/endocrine interactions between the neuroendocrine-adipose-gonadal axis in the fly model.
Aim 2. Contribution of adipose tissue to the PCOS-like phenotype.
Aim 3. Unraveling new (epi)genetic and metabolic markers in adolescents and young adult women (AYAs) with
PCOS.
Methods: In the animal model, single-cell transcriptomics and epigenomics (scRNA-seq, scATAC-seq) and lipidomics in larval neuroendocrine organ, gonads and adipose tissue, and analysis of the inter-organ network involved in PCOS, followed by nutritional/pharmacological interventions. In humans, in silico analysis and clinical study in AYAs with PCOS vs healthy controls to validate the biomarkers identified in the fly model. Expected results: Our project will help elucidate the cell-autonomous/hormonal mechanisms involved in PCOS. This will translate into clinical research by identifying potential biomarkers for early diagnosis of PCOS.

Codi

2024 DI 00137

Investigador/a principal

Patricia Garcia Cañadilla

Rol

Individual

Any d'inici

2025

Any de finalització

2028

Import total

22800€

Objectius

AGAUR_García Cañadilla, Patricia

Codi

CD24/00026

Investigador/a principal

Susana Ochoa Güerre

Rol

Individual

Any d'inici

2025

Any de finalització

2028

Import total

95000€

Objectius

ISCIII_Susana Ochoa

Codi

CD24/00244

Investigador/a principal

Francesca Crovetto

Rol

Individual

Any d'inici

2025

Any de finalització

2028

Import total

95000€

Objectius

ISCIII_Francesca Crovetto

Codi

SOC088/24/000123

Investigador/a principal

Roser Arnalte Olloquequi

Rol

Individual

Any d'inici

2025

Any de finalització

2026

Import total

43225€

Objectius

Servei Públic d'Ocupació de Catalunya_Arnalte Olloquequi, Roser

Investigador/a principal

Jaume Català Mora

Rol

Individual

Any d'inici

2025

Any de finalització

2026

Import total

20000€

Objectius

El projecte sorgeix de la necessitat de crear un sistema que permeti avaluar la visió funcional de la població general i dels pacients que presenten distròfia hereditària de retina (DHR), per observar la seva evolució i estat abans i després de ser sotmesos a teràpies avançades.
Actualment els mètodes d’avaluació funcional a través de circuits físics, requereixen infraestructures cares i complicades de modular i estan a l’abast de pocs centres d’investigació. És molt complicat poder replicar aquests laberints en els centres de tractament, un cop s’estén l’ús d’aquestes teràpies avançades.
La solució que es planteja en aquest projecte té com a finalitat estar a l’abast de tots els professionals que vulguin utilitzar-lo, ja que gràcies a la seva eficàcia, facilitat d’ús i d’implementació sigui possible instal·lar-lo en qualsevol centre de tractament.
El producte final consisteix en crear una eina de diagnòstic utilitzant la realitat virtual (RV), que mesura la visió funcional de la població i dels pacients amb DHR, per tant, és capaç de determinar l’eficàcia de les teràpies intraoculars avançades. La solució consta d’un casc de RV i un Serious Game que recrearà un laberint virtual del recorregut, els obstacles i la il·luminació del mateix.

Investigador/a principal

Eduard Gratacós Solsona

Rol

Individual

Any d'inici

2025

Any de finalització

2026

Import total

20000€

Objectius

CONSORCI DE SALUT I SOCIAL DE CATALUNYA_Eduard Gratacós

Codi

FI24/00075

Investigador/a principal

Rafael Artuch Iriberri

Rol

Individual

Any d'inici

2025

Any de finalització

2029

Import total

89900€

Objectius

ISCIII_Rafa Artuch

Codi

SLT035/24/000065

Investigador/a principal

Andrea Fontán Abeijón

Rol

Individual

Any d'inici

2025

Any de finalització

2027

Import total

75000€

Objectius

DEPARTAMENT DE SALUT_Andrea Fontán