Proyectos

Código

RYC2019-027738-I

Investigador/a principal

Alexandra Avgustinova

Rol

Individual

Año de inicio

2020

Año de finalización

2025

Import total

208600€

Objectius

MINECO_RAMON Y CAJAL_Alexandra Avgustinova

Código

874583

Investigador/a principal

Maria Dolores Gómez Roig

Rol

Participant

Año de inicio

2020

Año de finalización

2024

Import total

38375€

Objectius

ATHLETE aims to develop a toolbox of advanced, next-generation, exposome tools and a prospective exposome cohort, which will be used to systematically quantify the effects of a wide range of community-level and individual-level
environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways during the first 2 decades of life, to implement acceptable and feasible exposome interventions, and to translate the resulting
evidence to policy recommendations and prevention strategies.
ATHLETE will establish a prospective exposome cohort, including FAIR data infrastructure, building on Europe’s most comprehensive already existing exposome data (15 cohorts in 10 European countries). ATHLETE will systematically
characterise the effects of the exposome on early organ development, health trajectories, and biological pathways (metagenomic, metabolomic, epigenetic, ageing, and stress pathways), longitudinally from early pregnancy through
adolescence. Innovative tool development will focus on: 1) complete and accurate measurement of multiple environmental risk factors (external/urban, chemical, physical, behavioural, social) through new targeted and untargeted exposure science
approaches, 2) development of advanced statistical and toxicological strategies to analyse complex multi-dimensional exposome data, 3) development of interventions to reduce personal exposures, co-produced with the community, and 4)
estimation of the societal impact of the exposome by calculating costs and child health impacts.
ATHLETE’s strong focus on the vulnerable early stages of the life course, widespread general population exposures and common non-communicable diseases, its use of a large body of existing exposome data and expertise, its strong emphasis
on knowledge translation, and its development of an open online toolbox for use beyond the project, ensure that the objectives are achievable and highly relevant for future research and policy.