Objectiu de la convocatòria

TRANSCAN-2 has the goal of coordinating national and regional funding programmes for research in the area of translational cancer research. The specific challenge is to promote a transnational collaborative approach between scientific teams in demanding areas of translational cancer research while avoiding the duplication of efforts and ensuring a more efficient use of available resources, to produce significant results of higher quality and impact, and share data and infrastructures.

The EC co-funded call of TRANSCAN-2 (JTC 2014) will focus on: "Translational research on human tumour heterogeneity to overcome recurrence and resistance to therapy"

"Human tumour heterogeneity" is defined in this call as heterogeneity within the tumour or between the primary tumour and metastatic sites within a same patient. In the context of Translational Research, this topic will comprise three specific aims which concur to the possible clinical applications. Proposals will have to cover at least one of the specific areas listed under each aim below. Projects should be built from a solid and established hypothesis and should be relevant with regards to the possible improvements in clinical practices.

Característiques principals

Aims of the call

Aim 1: Development and validation of methods to investigate human tumour heterogeneity (including heterogeneity between the primary tumour and the metastatic sites)

Aim 2: Studies on human tumour heterogeneity in order to guide therapeutic intervention and identify new therapeutic targets

Aim 3: Development of new precision therapeutic strategies that may prevent human tumour recurrence or resistance to therapy by counteracting tumour heterogeneity

The following types of research projects are excluded from the call:

•Studies on inter-tumour heterogeneity meaning research exploring heterogeneity between tumours from different patients.

•Studies focusing on tumour micro-environment heterogeneity only.

•Analysis of preclinical models (cell lines and animal models) only.

•Phase III and IV clinical trials.

•Studies not compliant with the COMMISSION REGULATION (EC) No 800/2008 (http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2008:214:0003:0047:en:PDF<, with specific reference to the articles 30, 31, 32, and 33. For full reference, please see also the COMMUNICATION FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT, THE COUNCIL, THE EUROPEAN ECONOMIC AND SOCIAL COMMITTEE AND THE COMMITTEE OF THE REGIONS of 20.12.2011 (http://ec.europa.eu/services_general_interest/docs/comm_quality_framework_en.pdf<). Studies non compliant with the Commission Regulation (EU) No 651/2014 of 17 June 2014 http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=OJ:L:2014:187:FULL&from=EN<2.2

Convocatòria (URL)

http://www.transcanfp7.eu/transcan/mod/resource/view.php?id=87

Informació addicional

Aplicatiu web:

https://www.pt-it.de/ptoutline/application/Cancer13

Requisits

Only transnational projects will be funded. Each research consortium must involve a minimum of four (4) research groups and a maximum of seven (7) research groups. The groups must be from at least four (4) different countries participating in the call. In addition, a consortium must not involve more than two (2) research groups from one country (in such cases the minimum number of groups must be 5, coming from 4 different countries). Consortium must involve at least one basic or pre-clinical research team and one clinical team. Please check section 4.1 of the Call text for more details.

While applications will be submitted by the coordinator, the individual research groups will be funded by the funding organisation from their country/region that is participating in the TRANSCAN-2 JTC 2014. The applications are therefore subject to eligibility criteria of national/regional funding organisations. Applicants should refer to the annexes of the document "Guidelines for Applicants" containing all the specific national/regional eligibility criteria and should contact their respective national/regional funding organisation contact points for additional clarification (see Annex 1 of the Call text. Contact information of the national/regional funding organisations).

Dotació

For Spanish participants:

up to 100,000 € (overheads included) per project partner (up to 150,000 € per project for the whole Spanish part funded by ISCIII in case more than one Spanish partner participates in the same proposal);

up to 150.000 € (overheads included) per project coordinator (up to 200.000 € for the whole Spanish part funded by ISCIII in case one Spanish eligible institution coordinates the project consortium).

Durada

3 years

AVÍS IMPORTANT

Only one application can be submitted per Spanish project partner: Additional submissions will be rejected.

Us preguem respecteu el termini màxim de presentació d'Expressions d'Interès per tal de permetre el procés intern de selecció de la proposta que es podrà presentar a la convocatòria. Donades les característiques de la convocatòria, contacteu amb Leonor Norton (lnorton@fsjd.org) amb la màxima antelació possible.