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The ADDF supports promising, diverse international research projects to develop new drugs for Alzheimer's and related dementias, including vascular, Lewy body, and frontotemporal dementias, through 4 funding mechanisms: Drug Discovery, Program to Accelerate Clinical Trials (PACT), Neuroimaging and CSF Biomarker Development, and Prevention Beyond the Pipeline.

Main features

FUNDING MECHANISMS:

- Drug Discovery RFP: The goal of this RFP is to develop therapeutics for Alzheimer's disease and related dementias. This RFP focuses on building preclinical evidence in animal models and on advancing lead molecules to the clinical candidate selection stage. The proposed studies should have a high probability of reaching IND-enabling studies within two years.

- Program to Accelerate Clinical Trials (PACT) RFP: The goal of this RFP is to increase the number of innovative pharmacologic interventions tested in clinical studies for Alzheimer’s disease and related dementias. This includes novel, repurposed, and repositioned drugs as well as natural products.

- Neuroimaging and CSF Biomarker Development RFP: The aim of this RFP is to develop biomarkers for which there is a clear clinical need in Alzheimer's disease and related dementias.

- Prevention Beyond the Pipeline RFP: The RFP supports comparative effectiveness research, prevention clinical trials, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline

Funding

- Drug discovery: up to $600,000

- Program to accelerate clinical trials : up to $3 million

- Neuroimaging and CSF biomarker development program: up to $600,000

- Prevention beyond the pipeline: $50,000-$100,000 (epidemiological analyses), up to $3 million for clinical trials

Duration

- Drug discovery: 1 year, potential for follow-up funding

- Program to accelerate clinical trials : multi-year, potential for follow-up funding

- Neuroimaging and CSF biomarker development program: 1-2 years, potential for follow-up funding

- Prevention beyond the pipeline: multi-year, potential for follow-up funding

Deadline

- January 17, 2020

- April 10, 2020

- July 10, 2020

- October 9, 2020

In case of interest, contact with Research's Department before January 10, 2020.