In Horizon Europe program, Cluster Health, has opened one two-stage call under destination 5 Unlocking the full potential of new tools, technologies and digital solutions for a healthy society with deadline for the first stage on the 19^th September 2023:

HORIZON-HLTH-2024-TOOL-05-06-two-stage: Innovative non-animal human-based tools and strategies for biomedical research.

The proposal(s) should develop and/or use tools and strategies that address critical areas of biomedical research where animal-models are currently used but are of limited translational value for investigation and development of prevention and treatment. Such advanced tools and strategies should aim at a better understanding of the pathogenesis of disorders that feature a high impact on public health and exhibit a high rate of animal use or severe animal suffering, and enable to develop biomedical concepts with increased translational value, thereby ultimately leading to improved disease prediction, prevention and treatment.

Scope:

• The innovative tools and strategies should include a variety of technologies and methodological approaches such as -omics and other high-throughput procedures, human-derived cell-based material, organoids, micro-physiological systems, and insilico models.
• The newly proposed tools and strategies should demonstrably advance the state-of-theart in specific areas of biomedical research.
• Prospects and avenues for dissemination, knowledge sharing, uptake or translation into health policies of the proposed tools and strategies within the EU should be provided.
• Aspects such as harm and cost-benefit assessment as well as ease of production with respect to current practices should also be considered.
• Criteria for model qualification and standardisation should be developed in well-justified use-case contexts to demonstrate their translational values.

Budget per proposal: between 4 and 8 million euros, expected 3 to 6 projects finance. 

Research and Innovation Actions benefits from a grant that covers 100% of the project costs.

 Three legal entities established in 3 EU Member States or countries associated to Horizon Europe.

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